lipid-lowering activity of cow urine ark in guinea pigs fed with a high cholesterol diet

نویسندگان

hiren manubhai chawda department of pharmacology, government medical college, bhavnagar-364001, gujarat, india

divyesh rasiklal mandavia department of pharmacology, government medical college, bhavnagar-364001, gujarat, india

seema natvarlal baxi department of pathology, government medical college, bhavnagar-364001, gujarat, india

vishalkumar kishorbhai vadgama department of pharmacology, government medical college, bhavnagar-364001, gujarat, india

چکیده

objectives: cow urine ark (cua), known as “amrita” as mentioned in ayurveda, contains‎ anti-hyperglycemic and antioxidant effects. therefore, we designed the present study to evaluate the lipid ‎lowering activity of cua and its possible implication in metabolic syndrome.‎ materials and methods: thirty guinea pigs of either sex were divided into five groups: group 1 and 2 serving as a vehicle ‎and sham control, received normal and high fat diet for 60 days respectively; group 3, 4 and 5 ‎received high fat diet for 60 days with cua 0.8 ml/kg, 1.6 ml/kg and rosuvastatin (1.5 mg/kg) on the‎last 30 days of study period, respectively. serum lipid profile (total cholesterol, triglycerides, ldl-‎c, vldl-c, hdl-c, total cholesterol/hdl-c) and serum enzymes (alt, ast, alp, ldh and ck-mb) ‎were performed in each group at the beginning and end of the study. histological study of liver and ‎kidney was done in each group. results: cua (0.8 ml/kg) significantly decreased the serum triglycerides and vldl-c, but cua (1.6 ml/kg) ‎decreased the total serum cholesterol, triglycerides and vldl-c (p < 0.05). higher dose (1.6 ml/kg) of ‎cua also increased hdl-c level, significantly (p < 0.05). cua reduced serum ast, alp and ldh ‎level, which was statistically significant as well, while it also decreased the accumulation of lipid in hepatocytes as ‎compared to sham control.‎ conclusions: cua reduced triglycerides, increased hdl-c and found to be hepatoprotective in ‎animals that are on a high fat diet.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Lipid-lowering activity of Cow urine ark in guinea pigs fed with a high cholesterol diet

Objectives: Cow urine ark (CUA), known as “Amrita” as mentioned in Ayurveda, contains‎ anti-hyperglycemic and antioxidant effects. Therefore, we designed the present study to evaluate the lipid ‎lowering activity of CUA and its possible implication in metabolic syndrome.‎ Materials and Methods: Thirty guinea pigs of either sex were divided into five groups: Group 1 and 2 serving as a vehicle ‎a...

متن کامل

Lipid-lowering activity of Cow urine ark in guinea pigs fed with a high cholesterol diet

OBJECTIVES Cow urine ark (CUA), known as "Amrita" as mentioned in Ayurveda, contains‎ anti-hyperglycemic and antioxidant effects. Therefore, we designed the present study to evaluate the lipid ‎lowering activity of CUA and its possible implication in metabolic syndrome.‎ MATERIALS AND METHODS Thirty guinea pigs of either sex were divided into five groups: Group 1 and 2 serving as a vehicle ‎a...

متن کامل

Cholesterol absorption and steroid excretion in cholesterol-fed guinea pigs.

Cholesterol absorption was studied in groups of guinea pigs fed diets containing 0, 0.1%, or 1% cholesterol. A similar proportion of tracer cholesterol was absorbed regardless of the cholesterol content of the diet. Furthermore, the proportion of tracer cholesterol absorbed by individual animals did not change when the cholesterol-free diet was changed to one containing 1% cholesterol. Choleste...

متن کامل

Lipid-lowering effects of methanolic extract of Vernonia amygdalina leaves in rats fed on high cholesterol diet

We investigated the lipid-lowering effects of methanolic extract of Vernonia amygdalina (VA) leaves in rats fed an high cholesterol diet, and compared with a standard hypolipidemic drug, Questran (Qu). The effects of VA on the lipid profile were assessed by measuring the levels of total cholesterol, triglyceride, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) choleste...

متن کامل

Decreased expression of stem cell factor mRNA and protein in the gallbladders of guinea pigs fed on high cholesterol diet.

OBJECTIVE Sufficient evidence suggests that the c-kit protooncogene receptor and its ligand stem cell factor (scf) signal pathway play a crucial role in interstitial cells of Cajal (ICCs) development and maintenance of their phenotype. We aimed to determine the expressions of scf mRNA and scf protein in the gallbladders in guinea pigs fed on high cholesterol diet (HCD). METHODS The gallbladde...

متن کامل

Antioxidant Activity and Lipid-Lowering Effect of Essential Oils Extracted from Ocimum sanctum L. Leaves in Rats Fed with a High Cholesterol Diet

It has been reported that Ocimum sanctum L. (OS) leaves decrease serum lipid profile in normal and diabetic animals. No experimental evidences support the anti-hyperlipidemic and antioxidative actions against hypercholesterolemia. Moreover the identity of the specific chemical ingredients in OS leaves responsible for these pharmacological effects are unknown. Since OS leaves are rich in essenti...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
avicenna journal of phytomedicine

جلد ۴، شماره ۵، صفحات ۳۵۴-۳۶۳

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023